Pan-cancer study of CCT5 published in Scientific Reports
Our pan-cancer analysis of the chaperonin subunit CCT5 has been published in Scientific Reports.
The study examines CCT5 across 33 tumour types, covering gene and protein expression, DNA methylation, genetic alteration, immune cell infiltration, correlation with tumour mutational burden and microsatellite instability, drug sensitivity, and prognostic significance. CCT5 was overexpressed in most tumours and associated with poorer overall and disease-free survival in several of them; reduced promoter and N-shore methylation points to an epigenetic component, and amplification was the most common alteration observed.
The work was led by undergraduate researchers working through the centre’s supervision programme, from the initial question to the submitted manuscript.